In December of 2016, Columbia University and other New York City research institutions* hosted a one-day symposium to showcase a robust discussion of reproducibility and research integrity among leading experts, high-profile journal editors, funders and researchers. This program revealed the "inside story" of how issues are handled by institutions, journals and federal agencies and offered strategies for responding to challenges in these areas. Researchers in all stages of their career joined for a stimulating discussion. We are looking forward to continuing the discussion in a future event.