Principal Investigator(s)
Brent Stockwell, Professor of Biological Sciences and of Chemistry
Description: Given that anti-viral protease inhibitors have served as breakthrough treatments for other viral infections such as HIV, and given that the structure of the SARS-CoV-2 3CL protease has been reported, Drs. Brent Stockwell and David Ho propose that structure-guided discovery, optimization, and development of such protease inhibitors is feasible on a rapid timescale to develop a therapeutic option for treating COVID-19 patients. They are investigating optimization of compounds that already potently inhibit SARS1 and/or SARS2 3CL proteases and a screen of > 3 billion compounds for additional binders using a DNA-encoded library.
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