Stephen Sturley, PhD, "Probing reistance to COVID-19 in heterozygous carriers of Lysosomal Storage Disorders"
Clinical prognosis of infection by the SARS-CoV-2 virus can depend on an individual’s genome. Identifying genes mostly responsible for the outcome can accelerate treatment development. Dr. Struley and his team are statistically quantifying the prognosis of heterozygous Niemann Pick type C carriers to SARS-CoV-2 infection. Dr. Sturley also described the statistical methodology that can be used to derive this prognosis using basic information that by comparing outcomes to the general population in a retrospective cohort study, which can be used to rapidly estimate the advantage of these carriers. By studying the lysosomal storage disorders, whether lysosome is critical for COVID-19 can be investigated.
