Jingyue Ju: Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase
The SARS-CoV-2 virus uses an RNA-dependent RNA polymerase to replicate and Dr. Ju has experimentally identified five nucleotide analogues as inhibitors of the SARS-CoV-2 polymerase, four of which are FDA approved. He is hoping to determine whether these analogs could terminate the polymerase reaction. Remdesivir, with similar structure to drugs for hepatitis C and HIV, may be a candidate drug.
