Anthony Fehr, PhD, Assistant Professor, Department of Molecular Biosciences, University of Kansas, “On the Battlefront: Host PARPs vs the Coronavirus Macrodomain”
ADP-ribosylation is an important yet reversible process for example in cell stress reactions. Dr. Fehr presents how the Coronavirus’ macrodomain binds to mono-ADP-ribose and removes it via hydrolysis, which leads to a repression of poly-ADP-ribosylated proteins (PARP) which inhibit the viral replication. By introducing NAD+ enzymes, the PARP production is stimulated which therefore inhibits the viral replication.
