Reproducibility Resources and Guidelines by Topic

The following resources have been identified to aid researchers meet Rigor and Reproducibility Requirements from NIH as well as provide tools to researchers to ensure research is verifiable and reproducible.

Checklists and Validation Methods
Resources from Journals and Manufacturers
Literature Review
Guidelines and Resources from Professional and Non-Profit Organizations
  • Federation of American Societies for Experimental Biology
    Enhancing Research Reproducibility is a collection of recommendations from FASEB that resulted from roundtable discussions. This document discusses overarching topics, mouse and other animal models, and antibodies

  • Global Biological Standards Institute (GBSI)
    GBSI is a non-profit organization dedicated to enhancing the quality of biomedical research by advocating best practices and standards to accelerate the translation of research breakthroughs into life-saving therapies. (text taken from website) GBSI has assembled some key publications.

  • American Physiological Society Science Policy Committee's Scientific Rigor and Reproducibility Toolbox

Science Signaling
Statistics and Computational Analysis Specific for Biologists
Chemical Probes and Biomarkers

NIH suggests "applicants proposing to use cell lines could describe the method they plan to use to verify the identity and purity of the lines, which might include short tandem repeat (STR) profiling and mycoplasma testing." Below are some resources for writing an authentication plan and procedures for authenticating cell lines.

Guidelines and Resources from Professional and Non-Profit Organizations
Literature Review

Specific for Non-Human Cell Lines

Mixed Methods and Qualitative Research
Retrospective Chart Review
Preclinical and Clinical Research
Simulation-Based Research

The INSPIRE network has collaborated with global partners (including four influential journals: Simulation in Healthcare, BMJ Simulation, Clinical Simulation in Nursing, and Advances in Simulation) to develop extentions specific to simulation-based research for both the CONSORT and STROBE statements, in the documents below (text adapted from website).

These guidelines are for researchers who acquire images and use image manipulation software (such as Photoshop)

Online Training Courses
  • NIH-ORWH Course on Sex/Gender Differences. This online series of courses provides a foundation for sex and gender accountability in medical research and treatment. After completing the courses, researchers, clinicians, and students in the health professions will be able to integrate knowledge of sex and gender differences and similarities into their research and practice.
Resources for Considering Sex as a Biological Variable
Tutorials, Case Studies, Checklists and Reporting Guidelines
Literature Review
Center for Open Science (COS)

COS is part of the Open Science Framework (OSF), which has developed a series of online workshops as part of their statistical and methodological consulting services. These materials are free and can be found here, the webinars are also available on OSF's YouTube channel.

Literature Review
Statistics and Computational Analysis Specific for Biologists