Functional and Structural Characterization of the SARS-CoV-2 E-Protein for Identification of Channel Blockers by Compound Repurposing

Andrew Marks, Clyde '56 and Helen Wu Professor of Molecular Cardiology (in Medicine), Professor of Physiology & Cellular Biophysics, Chair of Physiology and Cellular Biophysics at CUMC

The purpose of the project is to study the function and structure of the SARS-CoV-2 E protein ion channel and identify FDA approved drugs that block the channel and impair the viral life cycle that could be repurposed to treat COVID-19