Insights into Possible COVID-19 Antivirals from a Rare Neurodegenerative Disease

Szabolcs Marka, Walter O. LeCroy, Jr. Professor of Physics, Department of Physics

Drugs mimicking the effects of the rare neurodegenerative disease Niemann-Pick type C provide candidates for coronavirus treatment. These drugs block the actions of the NPC1 protein, whose proper functioning is predicted to be important for the coronavirus to enter cells and proliferate.