We have two projects:
1. Our lab has designed, following the announcement from engineering, a means to use the Ambu Bag for oxygen application using inexpensive electronics and 3D printable components. This can be quickly assembled for parts under $100, and could be a good plan for health systems that do not have access to sufficient ventilators. We have submitted the plan to Engineering, and are happy to send it to anyone interested. We feel that it has some advantages to another system developed by MIT.
2. We have published data prior that shows cellular mechanisms by which chloroquine alters endocytosis of pathogens in dendritic cells and macrophages via steps including pH collapse and a buildup of endocytic / autophagic organelles. Put very simply, this step traps the pathogens within organelles where RNA transcription cannot take place. While this paper was intended for an HIV crisis about a decade ago, the controls were with chloroquine, and we believe will pertain for COVID as well. This would help to better understand and develop better efficacy for this drug. Refer to PMID: 18282092
